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Future directions Given the scarcity of literature on tobacco and cannabis co-use in psychosis risk, our findings expand several avenues for future research

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However, drawbacks consist of side effects such as skin irritation from patches, gastrointestinal discomfort from gum or lozenges, and the potential for continued nicotine dependence if not used as directed

Most Nicotiana species are day-neutral perennials, which offer unique research benefits